MovDisordV3, Main, Exploration, bibRecord, 001163

Common Variation in the LRRK2 Gene is a Risk Factor for Parkinson's Disease

Identifieur interne : 001163 ( Main/Exploration ); précédent : 001162; suivant : 001164

Common Variation in the LRRK2 Gene is a Risk Factor for Parkinson's Disease

Auteurs : Ignacio F. Mata [États-Unis] ; Harvey Checkoway [États-Unis] ; Carolyn M. Hutter [États-Unis] ; Ali Samii [États-Unis] ; John W. Roberts [États-Unis] ; Hojoong M. Kim [États-Unis] ; Pinky Agarwal [États-Unis] ; Victoria Alvarez [Espagne] ; Renee Ribacoba [Espagne] ; Pau Pastor [Espagne] ; Oswaldo Lorenzo-Betancor [Espagne] ; Jon Infante [Espagne] ; Maria Sierra [Espagne] ; Pilar Gomez-Garre [Espagne] ; Pablo Mir [Espagne] ; Beate Ritz [États-Unis] ; Shannonl. Rhodes [États-Unis] ; Amy Colcher [États-Unis] ; Vivianna Van Deerlin [États-Unis] ; Kathryn A. Chung [États-Unis] ; Joseph F. Quinn [États-Unis] ; Dora Yearout [États-Unis] ; Erica Martinez [États-Unis] ; Federico M. Farin [États-Unis] ; Jia Y. Wan [États-Unis] ; Karen L. Edwards [États-Unis] ; Cyrus P. Zabetian [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:13-0063590

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Facteur risque.
Wicri :
- geographic : Espagne, États-Unis.

English descriptors

KwdEn :
- Aged, Female, Genetic Predisposition to Disease (genetics), Genetic Testing (methods), Genotype, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (genetics), Parkinson disease, Polymorphism, Single Nucleotide (genetics), Protein-Serine-Threonine Kinases (genetics), Risk Factors, Risk factor, Spain, United States.
MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases.
- geographic : Spain, United States.
- genetics : Genetic Predisposition to Disease, Parkinson Disease, Polymorphism, Single Nucleotide.
- methods : Genetic Testing.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Risk Factors.

Abstract

Background: Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear. Methods: We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P <.05) were then genotyped in an independent sample of 3617 cases and 2512 controls from the United States and Spain (tier 2). Logistic regression was used to model additive SNP genotype effects adjusted for age and sex among white individuals. Results: Two regions showed independent association with PD in tier 1, and SNPs in both regions were successfully replicated in tier 2 (rs10878226, combined odds ratio [OR], 1.20; 95% confidence interval [CI], 1.08-1.33; P = 6.3 x 10^-4; rs11176013, OR, 0.89; CI, 0.83-0.95; P = 4.6 x ₁₀-⁴). Conclusions: Our data suggest that common variation within LRRK2 conveys susceptibility for PD in individuals of European ancestry.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536918

Affiliations:

Le document en format XML

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<author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name>
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<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
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<author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name>
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<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Department of Neurology, Oregon Health and Science University</s1>
<s2>Portland, Oregon</s2>
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<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Portland VA Medical Center</s1>
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<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Department of Neurology, Oregon Health and Science University</s1>
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<s3>USA</s3>
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<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Portland VA Medical Center</s1>
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<placeName><region type="state">Washington (État)</region>
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<country>États-Unis</country>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Environmental and Occupational Health Sciences, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
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<country>États-Unis</country>
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</placeName>
<orgName type="university">Université de Washington</orgName>
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<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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<orgName type="university">Université de Washington</orgName>
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<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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<orgName type="university">Université de Washington</orgName>
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<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common Variation in the LRRK2 Gene is a Risk Factor for Parkinson's Disease</title>
<author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
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<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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</affiliation>
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<author><name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Environmental and Occupational Health Sciences, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
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<sZ>26 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W." last="Roberts">John W. Roberts</name>
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<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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</affiliation>
</author>
<author><name sortKey="Kim, Hojoong M" sort="Kim, Hojoong M" uniqKey="Kim H" first="Hojoong M." last="Kim">Hojoong M. Kim</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
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<sZ>1 aut.</sZ>
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<sZ>22 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
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<sZ>22 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name>
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<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
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<author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
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<s3>ESP</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ribacoba, Renee" sort="Ribacoba, Renee" uniqKey="Ribacoba R" first="Renee" last="Ribacoba">Renee Ribacoba</name>
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<s3>ESP</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
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<s3>ESP</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Clinica Universidad de Navarra, University of Navarra School of Medicine</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</s1>
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<sZ>10 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name>
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<s3>ESP</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Clinica Universidad de Navarra, University of Navarra School of Medicine</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</s1>
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<sZ>10 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:noRegion>
</affiliation>
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<author><name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</s1>
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<sZ>10 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>Espagne</country>
<wicri:noRegion>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, "Marques de Valdecilla" University Hospital</s1>
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<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="Maria" last="Sierra">Maria Sierra</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, "Marques de Valdecilla" University Hospital</s1>
<s2>Santander</s2>
<s3>ESP</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Santander</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gomez Garre, Pilar" sort="Gomez Garre, Pilar" uniqKey="Gomez Garre P" first="Pilar" last="Gomez-Garre">Pilar Gomez-Garre</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</s1>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Unidad de Trastornos del Movimiento, Servicio de Neurologia y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla</s1>
<s2>Seville</s2>
<s3>ESP</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</s1>
<s3>ESP</s3>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Unidad de Trastornos del Movimiento, Servicio de Neurologia y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla</s1>
<s2>Seville</s2>
<s3>ESP</s3>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
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<s3>USA</s3>
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<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Department of Environmental Health Sciences, School of Public Health, University of California Los Angeles</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Department of Neurology, School of Medicine, University of California Los Angeles</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rhodes, Shannonl" sort="Rhodes, Shannonl" uniqKey="Rhodes S" first="Shannonl." last="Rhodes">Shannonl. Rhodes</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Epidemiology, School of Public Health, University of California Los Angeles</s1>
<s2>Los Angeles, California</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name>
<affiliation wicri:level="2"><inist:fA14 i1="18"><s1>Department of Neurology, University of Pennsylvania</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Vivianna" sort="Van Deerlin, Vivianna" uniqKey="Van Deerlin V" first="Vivianna" last="Van Deerlin">Vivianna Van Deerlin</name>
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<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Department of Neurology, Oregon Health and Science University</s1>
<s2>Portland, Oregon</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Portland VA Medical Center</s1>
<s2>Portland, Oregon</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
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<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<affiliation wicri:level="2"><inist:fA14 i1="20"><s1>Department of Neurology, Oregon Health and Science University</s1>
<s2>Portland, Oregon</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="21"><s1>Portland VA Medical Center</s1>
<s2>Portland, Oregon</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martinez, Erica" sort="Martinez, Erica" uniqKey="Martinez E" first="Erica" last="Martinez">Erica Martinez</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M." last="Farin">Federico M. Farin</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Environmental and Occupational Health Sciences, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y." last="Wan">Jia Y. Wan</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L." last="Edwards">Karen L. Edwards</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Veterans Affairs Puget Sound Health Care System</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of Washington School of Medicine</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genetic Testing (methods)</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Risk Factors</term>
<term>Risk factor</term>
<term>Spain</term>
<term>United States</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term>
<term>United States</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Testing</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Facteur risque</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
<term>États-Unis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Common variants in the LRRK2 gene influence the risk of Parkinson's disease (PD) in Asians, but whether the same is true in European-derived populations is less clear. Methods: We genotyped 66 LRRK2 tagging single-nucleotide polymorphisms (SNPs) in 575 PD patients and 689 controls from the northwestern United States (tier 1). PD-associated SNPs (P <.05) were then genotyped in an independent sample of 3617 cases and 2512 controls from the United States and Spain (tier 2). Logistic regression was used to model additive SNP genotype effects adjusted for age and sex among white individuals. Results: Two regions showed independent association with PD in tier 1, and SNPs in both regions were successfully replicated in tier 2 (rs10878226, combined odds ratio [OR], 1.20; 95% confidence interval [CI], 1.08-1.33; P = 6.3 x 10<sup>-4</sup>
; rs11176013, OR, 0.89; CI, 0.83-0.95; P = 4.6 x <sub>10</sub>
-<sup>4</sup>
). Conclusions: Our data suggest that common variation within LRRK2 conveys susceptibility for PD in individuals of European ancestry.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Oregon</li>
<li>Pennsylvanie</li>
<li>Washington (État)</li>
</region>
<settlement><li>Seattle</li>
</settlement>
<orgName><li>Université de Washington</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
</region>
<name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name>
<name sortKey="Checkoway, Harvey" sort="Checkoway, Harvey" uniqKey="Checkoway H" first="Harvey" last="Checkoway">Harvey Checkoway</name>
<name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A." last="Chung">Kathryn A. Chung</name>
<name sortKey="Colcher, Amy" sort="Colcher, Amy" uniqKey="Colcher A" first="Amy" last="Colcher">Amy Colcher</name>
<name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L." last="Edwards">Karen L. Edwards</name>
<name sortKey="Farin, Federico M" sort="Farin, Federico M" uniqKey="Farin F" first="Federico M." last="Farin">Federico M. Farin</name>
<name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name>
<name sortKey="Hutter, Carolyn M" sort="Hutter, Carolyn M" uniqKey="Hutter C" first="Carolyn M." last="Hutter">Carolyn M. Hutter</name>
<name sortKey="Kim, Hojoong M" sort="Kim, Hojoong M" uniqKey="Kim H" first="Hojoong M." last="Kim">Hojoong M. Kim</name>
<name sortKey="Kim, Hojoong M" sort="Kim, Hojoong M" uniqKey="Kim H" first="Hojoong M." last="Kim">Hojoong M. Kim</name>
<name sortKey="Martinez, Erica" sort="Martinez, Erica" uniqKey="Martinez E" first="Erica" last="Martinez">Erica Martinez</name>
<name sortKey="Martinez, Erica" sort="Martinez, Erica" uniqKey="Martinez E" first="Erica" last="Martinez">Erica Martinez</name>
<name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
<name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F." last="Quinn">Joseph F. Quinn</name>
<name sortKey="Rhodes, Shannonl" sort="Rhodes, Shannonl" uniqKey="Rhodes S" first="Shannonl." last="Rhodes">Shannonl. Rhodes</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<name sortKey="Roberts, John W" sort="Roberts, John W" uniqKey="Roberts J" first="John W." last="Roberts">John W. Roberts</name>
<name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
<name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
<name sortKey="Van Deerlin, Vivianna" sort="Van Deerlin, Vivianna" uniqKey="Van Deerlin V" first="Vivianna" last="Van Deerlin">Vivianna Van Deerlin</name>
<name sortKey="Wan, Jia Y" sort="Wan, Jia Y" uniqKey="Wan J" first="Jia Y." last="Wan">Jia Y. Wan</name>
<name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
</noRegion>
<name sortKey="Gomez Garre, Pilar" sort="Gomez Garre, Pilar" uniqKey="Gomez Garre P" first="Pilar" last="Gomez-Garre">Pilar Gomez-Garre</name>
<name sortKey="Gomez Garre, Pilar" sort="Gomez Garre, Pilar" uniqKey="Gomez Garre P" first="Pilar" last="Gomez-Garre">Pilar Gomez-Garre</name>
<name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name>
<name sortKey="Infante, Jon" sort="Infante, Jon" uniqKey="Infante J" first="Jon" last="Infante">Jon Infante</name>
<name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name>
<name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name>
<name sortKey="Lorenzo Betancor, Oswaldo" sort="Lorenzo Betancor, Oswaldo" uniqKey="Lorenzo Betancor O" first="Oswaldo" last="Lorenzo-Betancor">Oswaldo Lorenzo-Betancor</name>
<name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name>
<name sortKey="Mir, Pablo" sort="Mir, Pablo" uniqKey="Mir P" first="Pablo" last="Mir">Pablo Mir</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name>
<name sortKey="Ribacoba, Renee" sort="Ribacoba, Renee" uniqKey="Ribacoba R" first="Renee" last="Ribacoba">Renee Ribacoba</name>
<name sortKey="Sierra, Maria" sort="Sierra, Maria" uniqKey="Sierra M" first="Maria" last="Sierra">Maria Sierra</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Common Variation in the LRRK2 Gene is a Risk Factor for Parkinson's Disease

Common Variation in the LRRK2 Gene is a Risk Factor for Parkinson's Disease

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	Movement Disorders (revue)
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